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    聯系方式

    E-mail:sunneyxie@pku.edu.cn
    辦公電話:+86-010-62744061 +1-617-4969925
    辦公地點:綜合科研樓301
    郵件地址:北京市海淀區頤和園路5號,100871

    研究組主頁:http://sunneyxielab.org/

    謝曉亮
    北京大學李兆基講席教授;BIOPIC 主任、研究員;ICG 主任、研究員
    個人履歷

    2019.11-現在,北京大學理學部主任

    2018.7-現在,北京大學李兆基講席教授

    2016.8-現在,北京未來基因診斷高精尖創新中心(ICG),主任

    2010-現在,北京大學生物醫學前沿創新中心(BIOPIC),研究員

    2010-2022.3,北京大學生物醫學前沿創新中心(BIOPIC),主任

    2009-現在,北京大學生命科學學院教授

    2009-2018,哈佛大學化學與化學生物學系,Mallinckrodt講席教授

    1999-2009,哈佛大學化學與化學生物學系,終身教授

    1992-1998,美國太平洋西北國家實驗室(PNNL),環境分子科學實驗室,Senior Research Scientist to Chief Scientist,是PNNL1965年成立以來第一位來自中國的科學家

    1990-1992,美國芝加哥大學博士后研究

    1990,理學博士,美國加州大學圣地亞哥分校

    1984,理學學士,北京大學

    主要研究方向

    謝曉亮課題組目前的研究方向包含:

    (1)單細胞測序技術的開發。如單細胞基因組測序、轉錄組測序、甲基化測序、染色質三維結果解析、染色質開放性檢測以及單細胞多組學等; (2)單細胞測序技術在基因表達調控中的應用。如轉錄因子調控基因表達機理、早期胚胎發育過程中的表觀修飾動態變化、表觀遺傳如何協調影響基因調控網絡構建等; (3)單細胞測序技術在醫學轉化上的應用。如癌癥早期篩查診斷、無創產前遺傳篩查、高通量抗體藥物篩選等。

    謝曉亮教授是單分子酶學的創始人、單分子生物物理化學的奠基人之一、相干拉曼散射顯微成像技術和單細胞基因組學的開拓者。近年來,謝曉亮在基因組學、特別是單細胞測序技術方面取得了一系列重要成果,為生命科學和醫學的深入研究應用提供了重要的手段。

    獲獎及榮譽

    2022,突出貢獻中關村獎

    2017,中國科學院院士

    2017,求是杰出科學家獎

    2016,華人生物學家協會吳瑞獎

    2015,中國生物物理學會貝時璋生物物理獎

    2015,美國Albany 生物醫學獎

    2015,美國化學會Peter Debye 物理化學獎

    2014,美國光學會會士

    2014,德國洪堡學者

    2013,美國NIH Director's Pioneer Award

    2013,美國光學學會及應用光譜學會Ellis R. Lippincott獎

    2012,美國化學會Rochester分部Harrison Howe獎

    2012,美國微生物學會會士

    2012,美國生物物理學會Founders獎

    2010,中國化學會榮譽會士

    2009,美國能源部勞倫斯獎,化學類

    2008,美國物理學會會士

    2008,Berthold Leibinger Zukunftspreis激光獎

    2007,Willis E.Lamb激光科學與量子光學獎

    2006,美國科學促進會(AAAS)會士

    2006,美國生物物理學會會士

    2004,美國NIH Director's Pioneer Award

    2003,以色列Raymond and Beverly Sackler 物理科學獎

    1996,Coblentz協會,Coblentz獎

    代表性論文及論著

     

    COVID-19

    1. Cao, Yunlong; ...; Shen, Zhongyang; Wang, Youchun; Xie, Xiaoliang Sunney*."Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution," Nature DOI: 10.1038/s41586-022-05644-7 (2022)
    2. Cao, Yunlong; ...; Xiao, Junyu; Xie, Xiaoliang Sunney*."Rational identification of potent and broad sarbecovirus-neutralizing antibody cocktails from SARS convalescents," Cell Reports DOI: 10.1016/j.celrep.2022.111845 (2022)
    3. Cao, Yunlong; ...; Shen, Zhongyang; Wang, Youchun; Wang, Xiangxi; Xiao, Junyu; Xie, Xiaoliang Sunney*. "BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection," Nature 608, 593-602 DOI: 10.1038/s41586-022-04980-y (2022)
    4. Cao, Yunlong; ...; Wang, Xiangxi; Xiao, Junyu; Wang, Youchun; Xie, Xiaoliang Sunney*."Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies," Nature 602, 657-663 DOI: 10.1038/s41586-021-04385-3 (2021)
    5. Du, Shuo; Liu, Pulan; Zhang, Zhiying; Xiao, Tianhe; Yasimayi, Ayijiang; Huang, Weijin; Wang, Youchun; Cao, Yunlong; Xie, Xiaoliang Sunney; Xiao, Junyu "Structures of SARS-CoV-2 B.1.351 neutralizing antibodies provide insights into cocktail design against concerning variants," Cell Research 31, 1130–1133 DOI: 10.1038/s41422-021-00555-0 (2021)
    6. Cao, Yunlong; Yisimayi, Ayijiang; Bai, Yali; Huang, Weijin; Li, Xiaofeng; Zhang, Zhiying; Yuan, Tianjiao; An, Ran; Wang, Jing; Xiao, Tianhe; Du, Shuo; Ma, Wenping; Song, Liyang; Li, Yongzheng; Li, Xiang; Song, Weiliang; Wu, Jiajing; Liu, Shuo; Li, Xuemei; Zhang, Yonghong; Su, Bin; Guo, Xianghua; Wei, Yangyang; Gao, Chuanping; Zhang, Nana; Zhang, Yifei; Dou, Yang; Xu, Xiaoyu; Shi, Rui; Lu, Bai; Jin, Ronghua; Ma, Yingmin; Qin, Chengfeng; Wang, Youchun; Feng, Yingmei; Xiao, Junyu; Xie, Xiaoliang Sunney "Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines," Cell Research 31(7), 732-741 DOI: 10.1038/s41422-021-00514-9 (2021)
    7. Du, Shuo; Cao, Yunlong; Zhu, Qinyu; YU, Pin; Qi, Feifei; Wang, Guopeng; Du, Xiaoxia; Bao, Linlin; Deng, Wei; Zhu, Hua; Liu, Jiangning; Nie, Jianhui; Zheng, Yinghui; Liang, Haoyu; Liu, Ruixue; Gong, Shuran; Liu, Jiangning; Xu, Hua; Yisimayi, Ayijiang; Lv, Qi; Wang, Bo; He, Runsheng; Han, Yunlin; Zhao, Wenjie; Bai, Yali; Qu, Yajin; Gao, Xiang; Ji, Chenggong; Wang, Qisheng; Gao, Ning; Huang, Weijin; Wang, Youchun; Xie, X. Sunney; Su, Xiao-dong; Xiao, Junyu; Qin, Chuan "Structurally resolved SARS-CoV-2 antibody shows high efficacy in severely infected hamsters and provides a potent cocktail pairing strategy," Cell 183(4), 1013-1023.e13 DOI: 10.1016/j.cell.2020.09.035 (2020)
    8. Cao, Yunlong; Su, Bin; Guo, Xianghua; Sun, Wenjie; Deng, Yongqiang; Bao, Linlin; Zhu, Qinyu; Zhang, Xu; Zheng, Yinghui; Geng, Chenyang; Chai, Xiaoran; He, Runsheng; Li, Xiaofeng; Lv, Qi; Zhu, Hua; Deng, Wei; Xu, Yanfeng; Wang, Yanjun; Qiao, Luxin; Tan, Yafang; Song, Liyang; Wang, Guopeng; Du, Xiaoxia; Gao, Ning; Liu, Jiangning; Xiao, Junyu; Su, Xiaodong; Du, Zongmin; Feng, Yingmei; Qin, Chuan; Qin, Chengfeng; Jin, Ronghua; Xie, X. Sunney "Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients' B Cells," Cell 182(1), 73-84.e16 DOI: 10.1016/j.cell.2020.05.025 (2020)

    ??Single Molecule Spectroscopy and Imaging 

    1. Xie, X. Sunney; Dunn, Robert C. "Probing Single Molecule Dynamics" Science 265: 361-364 (1994).
    2. Sánchez, Erik J.; Novotny, Lukas; Xie, X. Sunney. "Near-field Fluorescence Microscopy Based on Two-photon Excitation with Metal Tips" Phys Rev Lett 82: 4014-4017 (1999).
    3. Min, Wei; Lu, Sijia; Chong, Shasha; Roy, Rahul; Holtom, Gary R.; Xie, X. Sunney. "Imaging Chromophores with Undetectable Fluorescence by Stimulated Emission Microscopy" Nature 461: 1105-1109 (2009).
    4. Chong, Shasha; Min, Wei; Xie, X. Sunney. "Ground-State Depletion Microscopy: Detection Sensitivity of Single-Molecule Optical Absorption at Room Temperature" J Phys Chem Lett 1:3316-3322 (2010).
    5. Zhou, Yuexin; Wang, Ping; Tang, Feng; Gao, Ge; Huang, Lei; Wei, Wensheng; Xie, X. Sunney “Painting a specific chromosome with CRISPR/Cas9 for live-cell imaging”, Cell Research, doi:10.1038/cr.2017.9 (2017).
    6. Cao, Yunlong; Wang, Jing; Jian, Fanchong; Xiao, Tianhe; Song, Weiliang; Yasimayi, Ayijiang; Huang, Weijin; Li, Qianqian; Wang, Peng; An, Ran; Wang, Jing; Wang, Yao; Niu, Xiao; Yang, Sijie; Liang, Hui; Sun, Haiyan; Li, Tao; Yu, Yuanling; Cui, Qianqian; Liu, Shuo; Yang, Xiaodong; Du, Shuo; Zhang, Zhiying; Hao, Xiaohua; Shao, Fei; Jin, Ronghua; Wang, Xiangxi; Xiao, Junyu; Wang, Youchun; Xie, Xiaoliang Sunney "Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies," Nature 602, 657-663 DOI: 10.1038/s41586-021-04385-3 (2021)

    Single Molecule Enzymology

    1. Lu, H. Peter; Xun, Luying; Xie, X. Sunney. "Single-Molecule Enzymatic Dynamics" Science 282: 1877-1882 (1998).
    2. Yang, Haw; Luo, Guobin; Karnchanaphanurach, Pallop; Louie, Tai-Man; Rech, Ivan; Cova, Sergio; Xun, Luying; Xie, X. Sunney. "Protein Conformational Dynamics Probed by Single-Molecule Electron Transfer" Science 302: 262-266 (2003).
    3. Min, Wei; Luo, Guobin; Cherayil, Binny J.; Kou, S. C.; Xie, X. Sunney. "Observation of a Power-Law Memory Kernel for Fluctuations within a Single Protein Molecule" Phys Rev Lett 94: 198302(1-4) (2005).
    4. English, Brian P.; Min, Wei; van Oijen, Antoine M.; Lee, Kang Taek; Luo, Guobin; Sun, Hongye; Cherayil, Binny J.; Kou, S.C.; Xie, X. Sunney. "Ever-Fluctuating Single Enzyme Molecules: Michaelis-Menten Equation Revisited" Nat Chem Bio 2: 87-94 (2006).
    5. Blainey, Paul C.; Luo, Guobin; Ko9u, S.C.; Mangel, Walter F.; Verdine, Gregory L.; Bagchi, Biman; Xie, X. Sunney. "Nonspecifically Bound Proteins Spin While Diffusing Along DNA" Nat Struct Mol Biol 16: 1224-1229 (2009).
    6. Kim, Sangjin; Brostr?mer, Erik, Xing, Dong; Jin, Jianshi; Chong, Shasha; Ge, Hao, Wang, Siyuan; Gu, Chan; Yang, Lijiang; Gao, Yiqin; Su, Xiao-dong; Sun, Yujie; Xie, X. Sunney. “Probing Allostery Through DNA” Science 339: 816-819 (2013).
    7. Chong, Shasha; Chen, Chongyi; Ge, Hao; Xie, X. Sunney. "Mechanism of Transcriptional Bursting in Bacteria" Cell 158: 314-326 (2014).

    Gene Expression and Regulation

    1. Yu, Ji; Xiao, Jie; Ren, Xiaojia; Lao, Kaiqin; Xie, X. Sunney. "Probing Gene Expression in Live Cells, One Protein Molecule at a Time" Science 311: 1600-1603 (2006).
    2. Cai, Long; Friedman, Nir; Xie, X. Sunney. "Stochastic Protein Expression in Individual Cells at the Single Molecule Level" Nature 440: 358-362 (2006).
    3. Elf, Johan; Li, Gene-Wei; Xie, X. Sunney. "Probing Transcription Factor Dynamics at the Single-Molecule Level in a Living Cell" Science 316: 1191-1194 (2007).
    4. Choi, Paul J.; Cai, Long; Frieda, Kirsten; Xie, X. Sunney. "A Stochastic Single-Molecule Event Triggers Phenotype Switching of a Bacterial Cell" Science 322: 442-446 (2008).
    5. Taniguchi, Yuichi; Choi, Paul J.; Li, Gene-Wei; Chen, Huiyi; Babu, Mohan; Hearn, Jeremy; Emili, Andrew; Xie, X. Sunney. "Quantifying E. coli Proteome and Transcriptome with Single-Molecule Sensitivity in Single Cells" Science 329: 533-538 (2010).
    6. Chong, Shasha; Chen, Chongyi; Ge, Hao; Xie, X. Sunney. "Mechanism of Transcriptional Bursting in Bacteria" Cell 158: 314-326 (2014).
    7. Ge, Hao; Qian, Hong; and Xie, X. Sunney. "Stochastic Phenotype Transition of a Single Cell in an Intermediate Region of Gene State Switching" Phys Rev Lett 114(7) (2015).

    Coherent Raman Microscopy

    1. Zumbusch, Andreas; Holtom, Gary R.; Xie, X. Sunney. “Vibrational Microscopy Using Coherent Anti-Stokes Raman Scattering" Phys Rev Lett 82: 4142-4145 (1999).
    2. Evans, Conor L.; Potma, Eric O.; Puoris'haag, Mehron; C?té, Daniel; Lin, Charles P.; Xie, X. Sunney. "Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy" Proc Nat. Aca Sci 102: 16807-16812 (2005).
    3. Freudiger, Christian W.; Min, Wei; Saar, Brian G.; Lu, Sijia; Holtom, Gary R.; He, Chengwei; Tsai, Jason C.; Kang, Jing X.; Xie, X. Sunney. "Label-Free Biomedical Imaging with High sensitivity by Stimulated Raman Scattering Microscopy" Science 322:1857-1860 (2008).
    4. Saar, Brian G.; Freudiger, Christian W.; Reichman, Jay; Stanley, C. Michael; Holtom, Gary R.; Xie, X. Sunney. "Video-Rate Molecular Imaging in Vivo with Stimulated Raman Scattering" Science 330: 1368-1370 (2010).
    5. Wang, Meng C.; Min, Wei; Freudiger, Christian W.; Ruvkun, Gary; Xie, X. Sunney. "RNAi Screening for Fat Regulatory Genes with SRS Microscopy" Nat Methods 8: 135-138 (2011).
    6. Ji, Minbiao; Orringer, Daniel A.; Freudiger, Christian W.; Ramkissoon, Shakti; Liu, Xiaohui; Lau, Darryl; Golby, Alexandra J.; Norton, Isaiah; Hayashi, Marika; Agar, Nathalie Y. R.; Young, Geoffrey S.; Spino, Cathie; Santagata, Sandro; Camelo-Piragua, Sandra; Ligon, Keith L.; Sagher, Oren; Xie, X. Sunney. "Rapid, Label-Free Detection of Brain Tumors with Stimulated Raman Scattering Microscopy" Science Translational Medicine 201: 201ra119 (2013).
    7. Fu, Dan; Zhou, Jing; Zhu, Wenjing Suzanne; Manley, Paul W.; Wang, Y. Karen; Hood, Tami; Wylie, Andrew; Xie, X. Sunney. "Imaging the Intracellular Distribution of Tyrosine Kinase Inhibitors in Living Cells with Quantitative Hyperspectral Stimulated Raman Scattering" Nat Chem 6: 614-622 (2014).

    Single Cell Genomics

    1. Tan, Longzhi; Xing, Dong; Chang, Chi-Han; Li, Heng; Xie, X. Sunney "Three-dimensional genome structures of single diploid human cells," Science 43, 924-928 (2018).
    2. Zong, Chenghang; Lu, Sijia; Chapman, Alec R.; Xie, X. Sunney. "Genome-Wide Detection of Single-Nucleotide and Copy-Number Variations of a Single Human Cell" Science 338: 1622-1626 (2012).
    3. Lu, Sijia; Zong, Chenghang; Fan, Wei; Yang, Mingyu; Li, Jinsen; Chapman, Alec R.; Zhu, Ping; Hu, Xuesong; Xu, Liya; Bai, Fan; Qiao, Jie; Tang, Fuchou; Li, Ruiqiang; Xie, X. Sunney. "Probing Meiotic Recombination and Aneuploidy of Single Sperm Cells by Whole-Genome Sequencing" Science 338: 1627-1630 (2012).
    4. Hou, Yu; Fan, Wei; Yan, Liying; Li, Rong; Lian, Ying; Huang, Jin; Li, Jinsen; Xu, Liya; Tang, Fuchou; Xie, X. Sunney; Qiao, Jie. "Genome Analyses of Single Human Oocytes" Cell 155: 1492-1506 (2013).
    5. Yan, Liying; Huang, Lei; Xu, Liya; Huang, Jin; Ma, Fei; Zhu, Xiaohui; Tang, Yaqiong; Liu, Mingshan; Lian, Ying; Liu, Ping; Li, Rong; Lu, Sijia; Tang, Fuchou; Qiao, Jie; Xie, X Sunney "Live Births after Simultaneous Avoidance of Monogenic Diseases and Chromosome Abnormality by Next-generation Sequencing with Linkage Analyses," Proc Natl Acad Sci USA, 112(52), 15964-15969,  (2015).
    6. Chen, Chongyi; Xing, Dong; Tan, Longzhi; Li, Heng; Zhou, Guangyu; Huang, Lei; Xie, X. Sunney "Single-cell whole-genome analyses by Linear Amplification via Transposon Insertion (LIANTI)," Science 356, 189-194 (2017).

    Key Review Articles

    1. Min, Wei; Freudiger, Christian W.; Lu, Sijia; Xie, X. Sunney. "Coherent Nonlinear Optical Imaging: beyond Fluorescence Microscopy" Annu. Rev. Phys. Chem. 62: 507-530 (2011).
    2. Li, Gene-Wei; Xie, X. Sunney. "Central Dogma at the Single-Molecule Level in Living Cells" Nature 475: 308-315 (2011).
    3. Xie, X. Sunney. "Enzyme Kinetics, Past and Present" Science 342: 1457-1459 (2013).
    4. Xie, X. Sunney. "Single Molecules Meet Genomics: Pinpointing Precision Medicine" JAMA 20: 2021-2 (2015).
    5. Huang Lei; Ma Fei; Chapman Alec; Lu Sijia; Xie X. Sunney. “Single-Cell Whole-Genome Amplification and Sequencing” Annu. Rev. Genomics Hum. Genet. 16: 79-102 (2015).
    6. Cheng, Ji-xin; Xie, X. Sunney. “Vibrational Spectroscopic Imaging of Living Systems: An Emerging Platform for Biology and Medicine” Science 350, aaa8870 (2015).